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博士論文 / Different distribution of mucosal-associated invariant T cells within the human cecum and colon 盲腸と結腸の粘膜におけるMAIT細胞に関する検討

著者

書誌事項

タイトル

Different distribution of mucosal-associated invariant T cells within the human cecum and colon

タイトル別名

盲腸と結腸の粘膜におけるMAIT細胞に関する検討

著者名

Hama Isamu

著者名

濱勇

学位授与大学

新潟大学 (大学ID:0035) (CAT機関ID:KI000356)

取得学位

博士(医学)

学位授与番号

甲第4490号

学位授与年月日

2018-09-20

注記・抄録

学位の種類: 博士(医学). 報告番号: 甲第4490号. 学位記番号: 新大院博(医)甲第827号. 学位授与年月日: 平成30年9月20日

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are involved in anti-bacterial immunity. MAIT cells are found in the intestine, but their role and distribution within the large intestine have not been fully elucidated. Therefore, we investigated the distribution of MAIT cells within the cecum and colon. Surgically resected tissues of the cecum and colon were obtained from 4 patients with cecal appendix cancer and 8 patients with colorectal cancer, respectively. Lymphocytes were isolated from the intestinal epithelium (intraepithelial lymphocytes, IELs) and the underlying lamina propria (lamina propria lymphocytes, LPLs), and then, MAIT cells were analyzed by flow cytometry. Compared with the colon, the cecum showed a significantly increased frequency of MAIT cells among IELs (P<0.01). CD69 expression on MAIT cells was significantly increased in the cecum and colon compared with that in the blood, and the frequency of natural killer group 2, member A^+ cells among MAIT cells was significantly increased in the cecum. These results suggest that the distribution of MAIT cells was different between the cecum and colon and that MAIT cells were more likely to be activated, especially in the intestinal epithelium of the cecum than in the colon and blood.

開始ページ : 1

終了ページ : 29

各種コード

NII論文ID(NAID)

500001085246

NII著者ID(NRID)
  • 8000001210811
  • 8000001210812
本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

博士論文 / 新潟大学 / 医学

博士論文 / 新潟大学

博士論文 / 医学

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