【博士論文】学術データベース

博士論文 / Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia 飢餓およびアデノシン誘発低体温へのオレキシン神経の関与

著者

書誌事項

タイトル

Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia

タイトル別名

飢餓およびアデノシン誘発低体温へのオレキシン神経の関与

著者名

二木貴弘

著者名

フタツキ タカヒロ

学位授与大学

鹿児島大学 (大学ID:0077) (CAT機関ID:KI000935)

取得学位

博士(医学)Doctor of Philosophy in Medical Science

学位授与番号

甲総研第472号

学位授与年月日

2018-08-20

注記・抄録

We examined whether orexin neurons might play a protective role against fasting- and adenosine-induced hypothermia. We first measured body temperature (BT) in orexin neuron-ablated (ORX-AB) mice and wild-type (WT) controls during 24 hours of fasting. As expected, the magnitude of BT drop and the length of time suffering from hypothermia were greater in ORX-AB mice than in WT mice. Orexin neurons were active just before onset of hypothermia and during the recovery period as revealed by calcium imaging in vivo using G-CaMP. We next examined adenosine-induced hypothermia via an intracerebroventricular administration of an adenosine A1 receptor agonist, N6-cyclohexyladenosine (CHA), which induced hypothermia in both ORX-AB and WT mice. The dose of CHA required to initiate a hypothermic response in ORX-AB mice was more than 10 times larger than the dose for WT mice. Once hypothermia was established, the recovery was seemingly slower in ORX-AB mice. Activation of orexin neurons during the recovery phase was confirmed by immunohistochemistry for c-Fos. We propose that orexin neurons play dual roles (enhancer in the induction phase and compensator during the recovery phase) in adenosine-induced hypothermia and a protective/compensatory role in fasting-induced hypothermia

元資料の権利情報 : CC BY

https://www.nature.com/srep/

各種コード

NII論文ID(NAID)

500001081406

NII著者ID(NRID)
  • 8000001205478
  • 8000001205479
DOI (出版社)

10.1038/s41598-018-21252-w

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

博士論文 / 鹿児島大学 / 医学

博士論文 / 鹿児島大学

博士論文 / 医学

関連著者

博士論文 / 大学

博士論文 / 学位