【博士論文】学術データベース

博士論文 / Echocardiographic Assessment of Cardiac Structural and Functional Abnormalities in Patients with End-Stage Renal Disease Receiving Chronic Hemodialysis

著者

書誌事項

タイトル

Echocardiographic Assessment of Cardiac Structural and Functional Abnormalities in Patients with End-Stage Renal Disease Receiving Chronic Hemodialysis

著者名

松尾浩司

著者名

Matsuo Hiroshi

学位授与大学

三重大学 (大学ID:0046) (CAT機関ID:KI000538)

取得学位

博士(医学)

学位授与番号

乙医学第1011号

学位授与年月日

2017-12-20

注記・抄録

Background: The aim of this study was to assess the echocardiographic characteristics of chronic hemodialysis (HD) patients with end-stage renal disease (ESRD) in a multicenter prospective cohort study. Methods and Results: Three hundred and fifteen patients with ESRD (67.9±10.6 years, 47.6% male) on chronic HD for ≥1 year were examined on transthoracic echocardiography, including Doppler-derived aortic valve area (AVA) measurement. Only 11.5% and 3.4% of all patients had normal left ventricular (LV) geometry and normal LV filling pattern, respectively. The majority of patients had aortic and mitral valvular calcification, and approximately 50% of all 315 patients had aortic valve narrowing with AVA <2.0 cm2. Patients were divided into 3 groups according to AVA index tertile: group 1, highest tertile; group 2, middle tertile; and group 3, lowest tertile. Group 3 was older, had a greater cardiothoracic ratio on chest X-ray, higher plasma brain natriuretic peptide and total LV afterload, and lower stroke volume index than the other 2 groups. Age and intact parathyroid hormone (PTH) level were independently associated with low AVA index. Conclusions: Patients with ESRD on chronic HD have a high prevalence of cardiac structural and functional abnormalities including calcified aortic sclerosis. High age and PTH were associated with aortic valve narrowing in these patients.

本文 / Department of Cardiology and Nephrology, Mie University Graduate School of Medicine

10p

内容の要旨・審査結果の要旨 / 三重大学大学院医学系研究科 生命医科学専攻 病態制御医学講座 腎臓内科学分野

キーワード

hemodialysis, Echocardiography, Aortic valve sclerosis, End-stage renal disease, Left ventricle

各種コード

NII論文ID(NAID)

500001054939

NII著者ID(NRID)
  • 8000001172705
  • 8000001172706
DOI (出版社)

10.1253/circj.CJ-17-0393

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

外部リンク

博士論文 / 三重大学 / 医学

博士論文 / 三重大学

博士論文 / 医学

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