【博士論文】学術データベース

博士論文 / Histopathological comparison of the onset of peri-implantitis and periodontitis in rats ラットにおけるインプラント周囲炎と歯周炎発症の病理組織学的検討

書誌事項

タイトル

Histopathological comparison of the onset of peri-implantitis and periodontitis in rats

タイトル別名

ラットにおけるインプラント周囲炎と歯周炎発症の病理組織学的検討

著者名

髙森雄三

学位授与大学

Nagasaki University (長崎大学) (大学ID:0073) (CAT機関ID:KI000877)

取得学位

博士(歯学)

学位授与番号

甲医歯薬第835号

学位授与年月日

2016-02-24

注記・抄録

Background and objective: There are a few experimental models that clearly describe the pathological differences in tissue destruction between periodontitis and peri-implantitis. We recently reported that the formation of immune complexes accelerates site-specific loss of attachment and alveolar bone resorption when an antigen is topically applied in the gingival sulcus of an immunized rat. We applied this model to the peri-implant tissues and compared peri-implant destruction to periodontitis without using a ligature. Material and methods: Twenty-five rats were used in this study and were divided into five groups. Implantation was performed immediately after extraction of right first molars in rats. The left first molars were left untreated to be examined as natural teeth. The immunized group consisted of rats that had received intraperitoneal lipopolysaccharide (LPS), whereas the nonimmunized group received only phosphate-buffered saline (PBS). The untreated baseline group received only implantation. After intraperitoneal booster injection, half of each group received topical application of LPS in the palatal gingival sulcus daily for 3 days. The other half of the groups received PBS. Histopathological and histometrical findings were observed with hematoxylin and eosin staining, collagen fibers were observed with Azan staining, and formation of immune complexes was immunohistologically evaluated by C1qB expression. Result: Peri-implant tissue destruction was greater in the immunized and LPS-applied groups than in the other groups. No periodontal destruction was observed. Formation of immune complexes was observed in the junctional epithelium and adjacent connective tissue in the immunized groups. Conclusion: Antigen-induced peri-implant tissue destruction occurs faster than periodontal tissue destruction.

開始ページ : 163

終了ページ : 170

元資料の権利情報 : © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

元資料の権利情報 : This is the peer reviewed version of the following article: Clinical Oral Implants Research, 28(2), pp.163-170; 2017, which has been published in final form at http://dx.doi.org/10.1111/clr.12777. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

キーワード

bone implant interactions, periodontology, soft tissue-implant interactions

各種コード プレビュー画像 / 博士論文 / Histopathological comparison of the onset of peri-implantitis and periodontitis in rats

NII論文ID(NAID)

500001051707

NII著者ID(NRID)
  • 8000001004924
DOI (出版社)

10.1111/clr.12777

DOI

info:doi/10.1111/clr.12777

本文言語コード

eng

データ提供元

機関リポジトリ, NDLデジタルコレクション

外部リンク

DOI

博士論文 / 長崎大学 / 歯学

博士論文 / 長崎大学

博士論文 / 歯学

博士論文 / 大学

博士論文 / 学位