【博士論文】学術データベース

博士論文 / Clinical, virological and epidemiological characterization of dengue outbreak in Myanmar, 2015 2015年にミャンマー国で発生したデング熱流行の臨床、ウイルス学、疫学解析

著者

書誌事項

タイトル

Clinical, virological and epidemiological characterization of dengue outbreak in Myanmar, 2015

タイトル別名

2015年にミャンマー国で発生したデング熱流行の臨床、ウイルス学、疫学解析

著者名

KYAW AUNG KYAW

学位授与大学

Nagasaki University (長崎大学) (大学ID:0073) (CAT機関ID:KI000877)

取得学位

博士(医学)

学位授与番号

甲医歯薬第984号

学位授与年月日

2017-09-20

注記・抄録

Hospital-based surveillance was conducted at two widely separated regions in Myanmar during the 2015 dengue epidemic. Acute phase serum samples were collected from 332 clinically diagnosed dengue patients during the peak season of dengue cases. Viremia levels were measured by quantitative real-time PCR and plaque assays using FcγRIIA-expressing and non-FcγRIIA-expressing BHK cells to specifically determine the infectious virus particles. By serology and molecular techniques, 280/332 (84·3%) were confirmed as dengue patients. All four serotypes of dengue virus (DENV) were isolated from among 104 laboratory-confirmed patients including two cases infected with two DENV serotypes. High percentage of primary infection was noted among the severe dengue patients. Patients with primary infection or DENV IgM negative demonstrated significantly higher viral loads but there was no significant difference among the severity groups. Viremia levels among dengue patients were notably high for a long period which was assumed to support the spread of the virus by the mosquito vector during epidemic. Phylogenetic analyses of the envelope gene of the epidemic strains revealed close similarity with the strains previously isolated in Myanmar and neighboring countries. DENV-1 dominated the epidemic in 2015 and the serotype (except DENV-3) and genotype distributions were similar in both study sites.

開始ページ : 1886

終了ページ : 1897

元資料の権利情報 : © Cambridge University Press 2017

元資料の権利情報 : This article has been published in a revised form in Epidemiology & Infection, http://doi.org/10.1017/S0950268817000735. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works.

キーワード

Viremia, Myanmar, molecular epidemiology, Clinical, 2015 dengue outbreak

各種コード

NII論文ID(NAID)

500001051763

NII著者ID(NRID)
  • 8000001153840
DOI (出版社)

10.1017/S0950268817000735

DOI

info:doi/10.1017/S0950268817000735

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

DOI

博士論文 / 長崎大学 / 医学

博士論文 / 長崎大学

博士論文 / 医学

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