【博士論文】学術データベース

博士論文 / Effect of scavenging circulating reactive carbonyls by oral pyridoxamine in uremic rats on peritoneal dialysis 尿毒症ラットの腹膜透析に対する、経口ピリドキサミンの活性カルボニル消去効果

著者

書誌事項

タイトル

Effect of scavenging circulating reactive carbonyls by oral pyridoxamine in uremic rats on peritoneal dialysis

タイトル別名

尿毒症ラットの腹膜透析に対する、経口ピリドキサミンの活性カルボニル消去効果

著者名

森良孝

学位授与大学

Nagasaki University (長崎大学) (大学ID:0073) (CAT機関ID:KI000877)

取得学位

博士(医学)

学位授与番号

甲医歯薬第901号

学位授与年月日

2016-12-07

注記・抄録

Pyridoxamine, a reactive carbonyl (RCO) scavenger, can ameliorate peritoneal deterioration in uremic peritoneal dialysis (PD) rats when given via dialysate. We examined the effects of scavenging circulating RCOs by oral pyridoxamine. Rats underwent nephrectomy and 3 weeks of twice daily PD either alone or with once daily oral pyridoxamine. PD solution was supplemented with methylglyoxal, a major glucose-derived RCO, to quench intraperitoneal pyridoxamine. Oral pyridoxamine achieved comparable blood and dialysate pyridoxamine concentrations, suppressed pentosidine accumulation in the blood but not in the mesenterium or dialysate, and reduced the increases in small solute transport and mesenteric vessel densities, with no effects on submesothelial matrix layer thickening or serum creatinine. Thus, reducing circulating RCOs by giving oral pyridoxamine with PD provides limited peritoneal protection. However, orally given pyridoxamine efficiently reaches the peritoneal cavity and would eliminate intraperitoneal RCOs. Oral pyridoxamine is more clinically favorable and may be as protective as intraperitoneal administration.

開始ページ : 645

終了ページ : 654

元資料の権利情報 : © 2016 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy

元資料の権利情報 : This is the accepted version of the following article: Therapeutic Apheresis and Dialysis, 20(6), pp.645-654; 2016, which has been published in final form at http://dx.doi.org/10.1111/1744-9987.12446

Pyridoxamine, a reactive carbonyl (RCO) scavenger, can ameliorate peritoneal deterioration in uremic peritoneal dialysis (PD) rats when given via dialysate. We examined the effects of scavenging circulating RCOs by oral pyridoxamine. Rats underwent nephrectomy and 3 weeks of twice daily PD either alone or with once daily oral pyridoxamine. PD solution was supplemented with methylglyoxal, a major glucose-derived RCO, to quench intraperitoneal pyridoxamine. Oral pyridoxamine achieved comparable blood and dialysate pyridoxamine concentrations, suppressed pentosidine

accumulation in the blood but not in the mesenterium or dialysate, and reduced the increases in small solute transport and mesenteric vessel

densities, with no effects on submesothelial matrix layer thickening or serum creatinine. Thus, reducing circulating RCOs by giving oral pyridoxamine with PD provides limited peritoneal protection. However, orally given pyridoxamine efficiently reaches the peritoneal cavity and would

eliminate intraperitoneal RCOs. Oral pyridoxamine is more clinically favorable and may be as protective as intraperitoneal administration.

キーワード

Peritoneal dialysis, Neovascularization, peritoneum, Carbonyl stress, Glucose degradation product, Mesothelium, Pentosidine

各種コード

NII論文ID(NAID)

500001049232

NII著者ID(NRID)
  • 8000001063545
DOI (出版社)

10.1111/1744-9987.12446

DOI

info:doi/10.1111/1744-9987.12446

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

外部リンク

DOI

博士論文 / 長崎大学 / 医学

博士論文 / 長崎大学

博士論文 / 医学

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