【博士論文】学術データベース

博士論文 / Extremely Low Genomic Diversity of Rickettsia japonica Distributed in Japan

著者

書誌事項

タイトル

Extremely Low Genomic Diversity of Rickettsia japonica Distributed in Japan

著者名

Arzuba Akter

著者名

Ooka Tadasuke

著者名

Gotoh Yasuhiro

著者名

Yamamoto Seigo

著者名

Fujita Hiromi

著者名

Terasoma Fumio

著者名

Kida Kouji

著者名

Taira Masakatsu

著者名

Nakadouzono Fumiko

著者名

Gokuden Mutsuyo

著者名

Hirano Manabu

著者名

Miyashiro Mamoru

著者名

Inari Kouichi

著者名

Shimazu Yukie

著者名

Tabara Kenji

著者名

Toyoda Atsushi

著者名

Yoshimura Dai

著者名

Itoh Takehiko

著者名

Kitano Tomokazu

著者名

Sato P. Mitsuhiko

著者名

Katsura Keisuke

著者名

Shakhinur Islam Mondal

著者名

Ogura Yoshitoshi

著者名

Ando Shuji

著者名

Hayashi Tetsuya

学位授与大学

宮崎大学 (大学ID:0109) (CAT機関ID:KI000913)

取得学位

博士(獣医学)

学位授与番号

甲第42号

学位授与年月日

2017-03-24

注記・抄録

以下に掲載:Genome Biology and Evolution , January 2017, Volume9 , Issue1 , pp 124–133 .

学位論文の一部を構成しているため、 に本文を掲載。

Rickettsiae are obligate intracellular bacteria that have small genomes as a result of reductive evolution. ManyRickettsia species of the spotted fever group (SFG) cause tick-borne diseases known as “spotted fevers". The life cycle of SFG rickettsiae is closely associated with that of the tick, which is generally thought to act as a bacterial vector and reservoir that maintains the bacterium through transstadial and transovarial transmission. Each SFGmember is thought to have adapted to a specific tick species, thus restricting the bacterial distribution to a relatively limited geographic region. These unique features of SFG rickettsiae allowinvestigation of how the genomes of such biologically and ecologically specialized bacteria evolve after genome reduction and the types of population structures that are generated. Here, we performed a nationwide, high-resolution phylogenetic analysis of Rickettsia japonica, an etiological agent of Japanese spotted fever that is distributed in Japan and Korea. The comparison of complete or nearly complete sequences obtained from 31 R. japonica strains isolated from various sources in Japan over the past 30 years demonstrated an extremely low level of genomic diversity. In particular, only 34 single nucleotide polymorphismswere identified among the 27 strains of themajor lineage containing all clinical isolates and tick isolates from the three tick species.Our data provide novel insights into the biology and genome evolution of R. japonica, including the possibilities of recent clonal expansion and a long generation time in nature due to the long dormant phase associated with tick life cycles.

キーワード

rickettsia, intracellular bacteria, intra-species genomic diversity, genome evolution, generation time

各種コード

NII論文ID(NAID)

500001048596

NII著者ID(NRID)
  • 8000001128803
  • 8000001128804
  • 8000001128805
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  • 8000001128809
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  • 8000001128825
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  • 8000001128827
DOI (出版社)

10.1093/gbe/evw304

DOI

http://doi.org/10.1093/gbe/evw304

本文言語コード

eng, eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

外部リンク

DOI

博士論文 / 宮崎大学 / 獣医学

博士論文 / 宮崎大学

博士論文 / 獣医学

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