【博士論文】学術データベース

博士論文 / Effect of e-beam sterilization on the in vivo performance of conventional UHMWPE tibial plates for total knee arthroplasty

著者

書誌事項

タイトル

Effect of e-beam sterilization on the in vivo performance of conventional UHMWPE tibial plates for total knee arthroplasty

著者名

刀根慎恵

著者名

Tone Shine

学位授与大学

三重大学 (大学ID:0046) (CAT機関ID:KI000538)

取得学位

博士(医学)

学位授与番号

甲医学第1858号

学位授与年月日

2017-09-20

注記・抄録

Although the introduction of highly cross-linked polyethylene is effective in reducing the amount of wear, there are still major concerns regarding the use of this material in total knee arthroplasty (TKA), essentially due to the reduction of fatigue resistance and toughness. Monitoring the in vivo performance of different types of UHMWPE is a much needed task to tackle the lack of information on which should be the most reliable choice for TKA. The present study was aimed at investigating the mid-term degradation of electron beam sterilized conventional UHMWPE tibial plates. Visual inspection enabled to grade the surface damage of 12 retrievals according to the Hood’s score: the total wear damage correlates to the in vivo time (Spearman’s q = 0.681, p < 0.05) and BMI (q = 0.834, p < 0.001). Surface degradation was less severe than that quantified in similar studies on c-sterilized UHMWPE. Raman and infra-red spectroscopies were utilized to unfold the microstructural modifications. In the load zone, polyethylene whitened damage regions were noticed in the inserts implanted longer than 1 year, in which oxidation index (OI) is clearly higher than 1 (max 8). The maximum OI (q = 0.802, p < 0.005) and ac (q = 0.816, p < 0.005) correlate to the implantation time in the load zone. The crystallinity increased along with the extent of oxidation. Concentration of absorbed species from synovial fluid is higher in the contact zone and correlates to maximum OI (Spearman’s q = 0.699, p = 0.011). Absorption was promoted in the contact area by the mechanical action of the femoral counterpart and it exacerbated the oxidative degradation in retrievals with high concentration of absorbed species. In the non-load zone, mild but detectable oxidation was observed, probably due to free radicals trapped after sterilization.

本文 / Department of Orthopaedic Surgery, Mie University, Graduate School of Medicine

11p

内容の要旨・審査結果の要旨 / 三重大学大学院医学系研究科 生命医科学専攻 臨床医学系講座 運動器外科学・腫瘍集学治療学分野

キーワード

Oxidation, UHMWPE, Raman spectroscopy, FT-IR, total knee arthroplasty, E-beam sterilization, Surface damage

各種コード

NII論文ID(NAID)

500001048620

NII著者ID(NRID)
  • 8000001159332
  • 8000001159333
DOI (出版社)

10.1016/j.actbio.2017.03.040

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

博士論文 / 三重大学 / 医学

博士論文 / 三重大学

博士論文 / 医学

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