【博士論文】学術データベース

博士論文 / Experimental Study and Clinical Application of Polyglycolic Acid Sheet with Fibrin Glue for Oral Soft Tissue Surgery 口腔内軟組織手術にフィブリン糊とポリグリコール酸シートを使用した実験的研究と臨床応用

著者

書誌事項

タイトル

Experimental Study and Clinical Application of Polyglycolic Acid Sheet with Fibrin Glue for Oral Soft Tissue Surgery

タイトル別名

口腔内軟組織手術にフィブリン糊とポリグリコール酸シートを使用した実験的研究と臨床応用

著者名

井口聡

学位授与大学

Nagasaki University (長崎大学) (大学ID:0073) (CAT機関ID:KI000877)

取得学位

博士(歯学)

学位授与番号

甲医歯薬第992号

学位授与年月日

2017-09-06

注記・抄録

Objective: The purpose of the present study was to examine the effects of a Polyglycolic acid (PGA) sheet with fibrin glue in the prevention of scar shrinkage. Methods: A PGA sheet with fibrin glue was grafted into the tongue after partial glossectomy in 25 rabbits. The wounds were examined histologically and compared to those of animals without grafts at 1, 2, 4, and 8 weeks after surgery, with particular focus on the change in the shape of the tongue and scar shrinkage. Furthermore, a retrospective study was conducted for cases in which the material was grafted into the raw surface of the tongue after partial glossectomy in 20 patients with early tongue cancer or leukoplakia. Postoperative pain and bleeding, and functional disadvantages were compared between the patients with PGA grafts and 6 patients that received partial glossectomy followed by a collagen-based artificial dermis graft. Results: In the animal experiment, less scar shrinkage was observed in rabbits receiving the graft of the PGA sheet with fibrin glue than in those with an open wound. Clinical application of the PGA sheet with fibrin glue indicated that the materials could prevent postoperative pain and functional disadvantages compared to collagen-based artificial dermis, although no statistical analysis was conducted on these results because of a historical controlled study with a small number of patients. Conclusions: The results of this study suggest that a PGA sheet with fibrin glue is useful for treating an open wound after soft tissue surgery of the oral cavity.

開始ページ : 295

終了ページ : 300

元資料の権利情報 : © 2017 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.

キーワード

oral surgery, fibrin glue, Polyglycolic acid sheet, Scar shrinkage

各種コード

NII論文ID(NAID)

500001045153

NII著者ID(NRID)
  • 8000001153844
DOI (出版社)

10.1016/j.ajoms.2017.02.006

DOI

info:doi/10.1016/j.ajoms.2017.02.006

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

DOI

博士論文 / 長崎大学 / 歯学

博士論文 / 長崎大学

博士論文 / 歯学

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