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博士論文 / Predictive values of egg-specific IgE by two commonly used assay systems for the diagnosis of egg allergy in young children: a prospective multicenter study

著者

書誌事項

タイトル

Predictive values of egg-specific IgE by two commonly used assay systems for the diagnosis of egg allergy in young children: a prospective multicenter study

著者名

古屋かな恵

著者名

Furuya Kanae

学位授与大学

三重大学 (大学ID:0046) (CAT機関ID:KI000538)

取得学位

博士(医学)

学位授与番号

甲医学第1795号

学位授与年月日

2016-09-21

注記・抄録

Background: Specific IgE (sIgE) is often used to predict oral food challenge (OFC) outcomes in food allergy, but interpretation of the results may vary depending on the assay method employed and the patient population tested. The aim of this study was to use two commercial assay systems to determine egg-sIgE values predictive of allergy within the most common populations treated at pediatric clinics. Methods: In a multicenter prospective study, 433 children with suspected or confirmed egg allergy underwent oral challenge (OFC) using cooked egg (CE) and raw egg (RE) powders to diagnose either true allergy in 1-year-old (group A, n = 220) or tolerance in 2- to 6-year-old (group B, n = 213). Egg white (EW)-and ovomucoid (OM)-sIgE values were measured using the ImmunoCAP® sIgE (ImmunoCAP) and the IMMULITE® 2000 3 gAllergyTM (3gAllergy) systems. Children were recruited from six primary care clinics and 18 hospitals in Japan. Results: Receiver-operating characteristic (ROC) curve analysis yielded similar areas under the curve (AUC) for the two assays (0.7–0.8). The optimal cutoff values and the probability curves (PCs) of the sIgE by the two assays to predict CE and RE OFC outcomes were determined for both groups. Values for 3gAllergy were higher than for ImmunoCAP; however, correlation of sIgE and predicted probability calculated by PCs were strong between the two methods. Conclusions: Cutoff values and PCs for egg-sIgE established using both Immuno-CAP and 3gAllergy may be useful for predicting egg allergy in early childhood patient populations.

本文 / Allergy Center and Institute for Clinical Research, Mie National Hospital

15p

内容の要旨・審査結果の要旨 / 三重大学大学院医学系研究科 生命医科学専攻 臨床医学系講座 成育医学分野

キーワード

egg allergy, value, oral food challenge, predictive, probability curve, specific IgE

各種コード

NII論文ID(NAID)

500001044310

NII著者ID(NRID)
  • 8000001153614
  • 8000001153615
DOI (出版社)

10.1111/all.12912

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

博士論文 / 三重大学 / 医学

博士論文 / 三重大学

博士論文 / 医学

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