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博士論文 / Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS) 2型糖尿病患者におけるうつ症状重症度と全死因死亡の関係に関する検討

著者

書誌事項

タイトル

Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS)

タイトル別名

2型糖尿病患者におけるうつ症状重症度と全死因死亡の関係に関する検討

著者名

Matsunaga Satoshi

著者名

松永佐澄志

学位授与大学

新潟大学 (大学ID:0035) (CAT機関ID:KI000356)

取得学位

博士(医学)

学位授与番号

甲第4361号

学位授与年月日

2017-09-20

注記・抄録

学位の種類: 博士(医学). 報告番号: 甲第4361号. 学位記番号: 新大院博(医)甲第774号. 学位授与年月日: 平成29年9月20日

Journal of Psychosomatic Research. 2017, 99, 34–39.

Objective: The aims of this study are to confirm whether the excess mortality caused by depressive symptoms is independent of severe hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and to evaluate the association between all-cause mortality and degrees of severity of depressive symptoms in Japanese patients with T2DM. Methods: A total of 1160 Japanese patients with T2DM were eligible for this analysis. Participants were followed prospectively for 3 years and their depressive states were evaluated at baseline by the Center for Epidemiologic Studies Depression Scale (CES-D). Cox proportional hazards model was used to evaluate the relative risk of allcause mortality and was adjusted by possible confounding factors, including severe hypoglycemia, all of which are known as risk factors for both depression and mortality. Results: After adjustment for severe hypoglycemia, each 5-point increase in the CES-D score was significantly associated with excess all-cause mortality (hazard ratio 1.69 [95% CI 1.26.2.17]). The spline curve of HRs for mortality according to total CES-D scores showed that mortality risk was slightly increased at lower scores but was sharply elevated at higher scores. Conclusion: A high score on the CES-D at baseline was significantly associated with all-cause mortality in patients with T2DM after adjusting for confounders including severe hypoglycemia. However, only a small effect on mortality risk was found at relatively lower levels of depressive symptoms in this population. Further research is needed to confirm this relationship between the severity of depressive symptoms and mortality in patients with T2DM.

元資料の権利情報 : (C) 2017 Elsevier Inc. All rights reserved.

キーワード

Diabetes Mellitus, Type 2, Depressive disorder, Death, Hypoglycemia

各種コード

NII論文ID(NAID)

500001044173

NII著者ID(NRID)
  • 8000001153891
  • 8000001153892
DOI (出版社)

10.1016/j.jpsychores.2017.05.020

DOI

info:doi/10.1016/j.jpsychores.2017.05.020

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

外部リンク

DOI

博士論文 / 新潟大学 / 医学

博士論文 / 新潟大学

博士論文 / 医学

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