【博士論文】学術データベース

博士論文 / Kidney morphological parameters measured using noncontrast- enhanced steady-state free precession MRI with spatially selective inversion recovery pulse correlate with eGFR in patients with advanced CKD 非造影SSFP-MRIによって計測された進行した慢性腎臓病患者の腎形態学的パラメーターは推定糸球体濾過量と相関する

著者

書誌事項

タイトル

Kidney morphological parameters measured using noncontrast- enhanced steady-state free precession MRI with spatially selective inversion recovery pulse correlate with eGFR in patients with advanced CKD

タイトル別名

非造影SSFP-MRIによって計測された進行した慢性腎臓病患者の腎形態学的パラメーターは推定糸球体濾過量と相関する

著者名

Otsuka Tadashi

著者名

大塚忠司

学位授与大学

新潟大学 (大学ID:0035) (CAT機関ID:KI000356)

取得学位

博士(医学)

学位授与番号

甲第4356号

学位授与年月日

2017-09-20

注記・抄録

学位の種類: 博士(医学). 報告番号: 甲第4356号. 学位記番号: 新大院博(医)甲第769号. 学位授与年月日: 平成29年9月20日

Clinical and Experimental Nephrology. First published online: 22 April 2017

Background It is well known that atrophic renal changes are associated with chronic kidney disease (CKD) progression, but conventional diagnostic imaging methods such as noncontrast-enhanced computed tomography and magnetic resonance imaging (MRI) have been insufficient for precisely assessing kidney function because they cannot clearly distinguish between the medulla and cortex. Hence, here we used noncontrast-enhanced steady-state free precession (SSFP) MRI with a spatially selective inversion recovery (IR) pulse to improve visibility for renal corticomedullary differentiation and evaluated the association between morphological parameters and kidney function in patients with CKD. Methods Kidney corticomedullary contrast ratio, cortical and medullary areas, and minimal cortical thickness of 107 patients with CKD G1–G5 were measured using SSFP MRI with a spatially selective IR pulse and the association between these morphological parameters and kidney function were evaluated. Results Corticomedullary contrast ratio was significantly improved on SSFP MRI compared with conventional inphase T1-weighted gradient-echo MRI and positively correlated with estimated glomerular filtration ratio (eGFR), raw eGFR, and 24-h creatinine clearance. The medullary and cortical areas and minimal cortical thickness also positively correlated with those of kidney functional markers and the age. In patients with CKD and diabetes mellitus (DM), the correlation coefficients between raw eGFR and morphological parameters were higher than those in patients without DM, while minimal cortical thickness was larger in CKD patients with DM with a raw eGFR ≥ 45 mL/min. Conclusion Kidney morphological parameters measured with SSFP MRI were clearly correlated with kidney function in patients with CKD, including those with advanced kidney dysfunction.

元資料の権利情報 : (C) The Author(s) 2017. This article is an open access publication.

キーワード

SSFP MRI, Cortical thickness, Cortical area, Medullary area

各種コード

NII論文ID(NAID)

500001044247

NII著者ID(NRID)
  • 8000001153889
  • 8000001153890
DOI (出版社)

10.1007/s10157-017-1413-x

DOI

info:doi/10.1007/s10157-017-1413-x

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

DOI

博士論文 / 新潟大学 / 医学

博士論文 / 新潟大学

博士論文 / 医学

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