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博士論文 / Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection 重症熱性血小板減少症候群(SFTS)ウイルス感染マウスモデルを用いた抗血清療法の治療効果

著者

書誌事項

タイトル

Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection

タイトル別名

重症熱性血小板減少症候群(SFTS)ウイルス感染マウスモデルを用いた抗血清療法の治療効果

著者名

嶋田聡

学位授与大学

Nagasaki University (長崎大学) (大学ID:0073) (CAT機関ID:KI000877)

取得学位

博士(医学)

学位授与番号

甲医歯薬第985号

学位授与年月日

2017-09-20

注記・抄録

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease that is endemic in China, Korea and Japan. No effective vaccine or specific treatment for SFTS is currently available. Here, we used a mouse model to examine the effects of ribavirin, site-1 protease inhibitor PF-429242, steroids, and combination of minocycline and ciprofloxacin (MC) on SFTS infection. The antiserum from a patient who recovered from SFTS was also examined for its effect on mice. Administration of antiserum completely protected mice against lethal infection with SFTSV. It could also protect mice from showing clinical signs of the disease due to non-lethal infection. MC-treatment resulted in prolonged survival times during lethal infection. Although other agents had no significant protective effects, they did not provide detrimental effects that could lead to progression of the disease in mice. Our results suggest that antiserum treatment may be clinically useful for post-exposure prophylaxis against SFTSV infection.

開始ページ : 19

終了ページ : 27

元資料の権利情報 : © 2015 Elsevier Inc. All rights reserved.

キーワード

Mouse model, Severe fever with thrombocytopenia syndrome, Ribavirin, Human antiserum, Post-exposure prophylaxis

各種コード

NII論文ID(NAID)

500001039891

NII著者ID(NRID)
  • 8000001148103
DOI (出版社)

10.1016/j.virol.2015.03.010

DOI

info:doi/10.1016/j.virol.2015.03.010

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

外部リンク

DOI

博士論文 / 長崎大学 / 医学

博士論文 / 長崎大学

博士論文 / 医学

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