【博士論文】学術データベース

博士論文 / TNFα is required for the production of T-type Ca²⁺ channel-dependent long-term potentiation in visual cortex. 視覚野においてT型Ca²⁺チャネル依存性長期増強を引き起こすためにはTNFαが必要である

著者

書誌事項

タイトル

TNFα is required for the production of T-type Ca²⁺ channel-dependent long-term potentiation in visual cortex.

タイトル別名

視覚野においてT型Ca²⁺チャネル依存性長期増強を引き起こすためにはTNFαが必要である

著者名

Sugimura Taketoshi

著者名

Yoshimura Yumiko

著者名

Komatsu Yukio

学位授与大学

奈良県立医科大学 (大学ID:1023) (CAT機関ID:KI001199)

取得学位

博士(医学)

学位授与番号

乙第1401号

学位授与年月日

2017-06-28

注記・抄録

Monocular deprivation produces depression and potentiation of visual responses evoked in visual cortical neurons by stimulation of deprived and nondeprived eyes, respectively, during the critical period of ocular dominance plasticity. Our previous studies suggested that T-type Ca²⁺ channel-dependent long-term potentiation (LTP), induced by 2 Hz stimulation, mediates the potentiation of visual responses. However, it was proposed that the experience-dependent response potentiation is mediated by tumor necrosis factor-α (TNFα)-dependent homeostatic synaptic scaling but not by Hebbian synaptic plasticity, because the potentiation was absent in TNFα knockout (TNFα-KO) mice. In this study, we investigated whether TNFα is required for LTP induced by 2 Hz stimulation using visual cortical slices prepared from critical period mice and rats. The production of LTP was prevented by pharmacological blockade of TNFα in rats and mice. LTP production was also prevented by an inhibitor of TNFα-converting enzyme that converts membrane-bound TNFα to soluble TNFα. In TNFα-KO mice, LTP did not occur and was rescued by exogenous soluble TNFα. Soluble TNFα was required for LTP production only during a restricted time window soon after 2 Hz stimulation. These results strengthen the view that T-type Ca²⁺ channel-dependent LTP contributes to the potentiation of nondeprived eye responses following monocular deprivation.

博士(医学)・乙第1401号・平成29年6月28日

Copyright © 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

開始ページ : 37

終了ページ : 44

PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/25701075

キーワード

Long-term potentiation, T-type Ca²⁺ channel, TNFα, Experience-dependent development, Ocular dominance plasticity, Visual cortex

各種コード

NII論文ID(NAID)

500001033504

NII著者ID(NRID)
  • 8000001142101
  • 8000001142102
  • 8000001142103
DOI (出版社)

10.1016/j.neures.2015.02.005

DOI

http://dx.doi.org/10.1016/j.neures.2015.02.005

本文言語コード

eng

データ提供元

機関リポジトリ / NDLデジタルコレクション

DOI

博士論文 / 奈良県立医科大学 / 医学

博士論文 / 奈良県立医科大学

博士論文 / 医学

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